Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002p051 | (1) | SRF2015

SPRASA knockout mice are sub-fertile

Prendergast Deborah , Liu Bonnia , Sheling Andrew Neil , Chamley Larry

Introduction: SPRASA is a protein, that is expressed in the acrosome of sperm, as wel as on the oolemma of many mammals, which we identified as the target of antisperm antibodies from some infertile men. In order to further understand the importance of SPRASA we produced knockout mice and examined the effect of this gene knockout on murine fertility.Methods: With ethics approval (AEC_R811) knockout mice were generated lacking the expression of exons 4 an...

ra0003o032 | Oral Communications 4: Early Development 2 | SRF2016

The target organs of human placental micro- and nano-vesicles

Chamley Larry , Tong Mancy , Stanley Jo , Chen Qi , Wise Michelle , James Joanna , Stone Peter

Introduction: The human placenta continuously extrudes, into the maternal circulation, vast quantities of extracellular vesicles (EVs) which have the ability to alter maternal physiology. There are three sizes of placental EVs multinucleated macro-EVs, subcellular micro- and nano- EVs. Macro-EVs are trapped in the maternal lungs due to their large size. We investigated the organs with which micro- and nano- EVs interact in vivo and their potential effects EVs on vascular funct...