Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002s003 | Symposia 1: The sperm race | SRF2015

Gamete interactions in the female reproductive tract: it is not a race!

Fazeli Alireza , Holt William Vincent

Until recently the mammalian oviducts or fallopian tubes were regarded as inert organs that provide a passive racecourse where spermatozoa compete against each other to reach the egg. Recent evidence suggests, however, that the female reproductive tract recognises the arrival of spermatozoa and initiates changes in gene expression and protein secretion profiles. We have observed that X- and Y-chromosome bearing spermatozoa alter gene expression in the maternal tract in differe...

ra0003o010 | Oral Communications 2: Early Development 1 | SRF2016

Investigating of the role of Tribbles-2 protein in mammalian embryo implantation

Basatvat Shaghayegh , Carter Deborah L.A. , Kiss-Toth Endre , Fazeli Alireza

Introduction: Embryo implantation is a complex and highly regulated process. Toll-Like receptors (TLRs) play a strategic role in recognition of pathogens in female reproductive tract. Activation of TLRs in endometrial cells at the time of embryo implantation appears to have negative effect on implantation. Tribbles-2 (Trib2) protein is members of tribbles family of psuedokinase proteins, modulating TLR5 signal transduction pathway.Tribbles-2 knockout female mice are infertile....

ra0003p013 | (1) | SRF2016

Characterisation of extracellular vesicles produced by the Porcine oviductal epithelial cells using size exclusion chromatography

Jamaludin Nurul Akmal , Basatvat Shagayegh , Aboussahoud Wedad , Elliott Sarah , Hunt Stuart , Peacock Ben , Ebbens Steven , Fazeli Alireza

Introduction: The interaction of gametes and embryo with the maternal environment has a crucial impact on gametes maturation, embryonic development and subsequent pregnancy success. Recent studies have recognised extracellular vesicles (EVs) as a potent vehicles for intercellular communication. Defining the type of EVs which are produced by different reproductive cells will help us to understand how these structures can influence reproductive processes. The aim of the current ...