Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002p051 | (1) | SRF2015

SPRASA knockout mice are sub-fertile

Prendergast Deborah , Liu Bonnia , Sheling Andrew Neil , Chamley Larry

Introduction: SPRASA is a protein, that is expressed in the acrosome of sperm, as wel as on the oolemma of many mammals, which we identified as the target of antisperm antibodies from some infertile men. In order to further understand the importance of SPRASA we produced knockout mice and examined the effect of this gene knockout on murine fertility.Methods: With ethics approval (AEC_R811) knockout mice were generated lacking the expression of exons 4 an...