ra0001s007 | Testis biology and spermatogenesis | WCRB2014
, Li Wei
Acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosome-related organelle (LRO) is still largely unknown. Here we show that germ cell specific Atg7 knockout mice were infertile due to defect in acrosome biogenesis and displayed a phenotype of human globozoospermia, and this reproductive defect was successfully rescued by...