Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001s005 | Testis biology and spermatogenesis | WCRB2014

The contributions of importin proteins to spermatogenesis: roles in signalling, gene transcription and stress responses

Miyamoto Yoichi , Whiley Penny , Young Julia , Arjomand Arash , Yoneda Yoshihiro , Jans David A , Loveland Kate L

Importin protein family members are best known for serving critical roles in mediating regulated nucleocytoplasmic transport, and many are essential to developmental events including gametogenesis. We proposed that coordinated expression of an importin and a cell-specific transcription factor would drive a developmental switch by enabling transcription and other nuclear factors to enter the nucleus appropriately. Analyses of importin alpha (IMPĪ±) and beta (IMPĪ²) mRNA...