Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003o019 | SRF Student Prize Session | SRF2016

Immune cell dynamics in endometrial repair and remodelling

Kirkwood Phoebe , Cousins Fiona , Saunders Philippa , Gibson Douglas

Introduction: The endometrium is one of the few adult tissues that heals repeatedly without scarring. On a monthly basis the endometrium undergoes cyclical episodes of proliferation, degeneration, tissue repair and remodelling in response to the ‘injury’ inflicted on it during menstruation. In women, endometrial shedding (menses) is the culmination of a cascade of inflammatory signals between uterine stromal cells and immune cells both of which have key roles in endo...

ra0001p274 | (1) | WCRB2014

A role for androgens in the regulation of endometrial breakdown and repair in a mouse model of menstruation

Cousins Fiona L , Murray Alison A , Critchley Hilary O D , Saunders Philippa T K

Background: The human endometrium is a dynamic, multi-cellular sex steroid-dependent tissue subject to cyclical episodes of breakdown (menses), repair and regeneration. The mechanisms responsible for initiation of menses are well characterised; the molecular and cellular changes responsible for rapid repair are poorly understood. Re-epithelialisation of the tissue is thought to involve contributions from both the stromal and epithelial compartments. A role for androgens in end...

ra0001p013 | Testis | WCRB2014

Exogenous androgens reduce the expression of INSL3, a hormone involved in normal testicular descent, in fetal Leydig cells

Duncan W Colin , Connolly Fiona , Boswell Lyndsey , Burt Graeme , McNeilly Alan S , Rae Mick

Introduction: Hypothalamo–pituitary–testicular feedback is intact in the ovine fetus. Exogenous testosterone suppresses fetal LH and testicular steroidogenesis to maintain normal circulating testosterone concentrations. INSL3 is a non-steroidal hormone secreted by the fetal testis whose roles include facilitating testicular descent. We hypothesised that the homeostatic response to increased androgens would have a detrimental effect on fetal INSL3 expression....

ra0001p294 | (1) | WCRB2014

Remodelling-associated processes during postpartum uterine involution in mice

Menzies Fiona M , Burton Laura , Ahmed Humera , Oldham Rachel S. , Higgins Claire A , Nelson Scott M , Nibbs Robert J B

Introduction: Following labour, the uterus rapidly returns to its pre-pregnancy state. Exact mechanisms underlying labour and postpartum involution are not fully understood but inflammation is understood to play a key role. It has been hypothesised that rather than initiating or propagating labour, inflammation may prime the uterus for extensive postpartum tissue repair and remodelling, in a manner akin to repair in exercising skeletal muscle. This study aims...

ra0001p321 | (1) | WCRB2014

Fetal overexposure to androgens, not estrogens, leaves a permanent legacy in terms of adrenal function in offspring

Ramaswamy Seshadri , Grace Cathal , Howie Forbes , Connolly Fiona , Konovalova Julia , McNeilly Alan S , Duncan W Colin , Rae Mick

Introduction: Overexposure to androgens during fetal life creates offspring with a polycystic ovary syndrome (PCOS)-like phenotype. Whether this phenotype is attributable to androgens during fetal life, or estrogens via maternal/placental metabolism, remains uncertain. The potential for in utero steroidal disruption of adrenal development and function is also unclear. We have examined the adrenal during development and adulthood in response to in utero androg...