Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003o017 | SRF Student Prize Session | SRF2016

Derivation and use of mouse embryonic stem cell lines as model for mechanistic analysis of periconceptional developmental programming

Khurana Pooja , Cox Andy , Fleming Tom , Smyth Neil

Introduction: The developmental origins of health and disease (DOHaD) concept proposes that maternal environment during pregnancy may influence offspring health and predispose to chronic disease risk in later life. Our previous mouse in vivo studies showed that maternal low protein diet (LPD) and advanced maternal age (AMA) programme the preimplantation embryo to adult disease, notably cardiometabolic dysfunction. To test this hypothesis and understand the mechanistic...