Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003o016 | SRF Student Prize Session | SRF2016

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS)

Siemienowicz Katarzyna , Coukan Flavien , Lerner Avigdor , Franks Stephen , Rae Mick , Duncan Colin

Women with Polycystic Ovary Syndrome are at increased risk of developing insulin resistance, obesity and dyslipidemia. Amplified metabolic perturbations during puberty may be a central factor contributing to metabolic phenotype of adult PCOS. Using a clinically realistic ovine model of PCOS we reported hyperinsulinaemia and early fatty liver changes, with no difference in body weight and adiposity, in adolescence.Here we aimed to further examine metaboli...

ra0003p061 | (1) | SRF2016

Altered expression of genes affecting oestrogen metabolism and action in granulosa-lutein cells of women with PCOS

Coates Melanie , Lerner Avigdor , Christopoulos Georgios , Liyanage Maneshka , Lavery Stuart , Tsui Victoria , Hardy Kate , Franks Stephen

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in premenopausal women and is associated with hyperandrogenism, anovulatory infertility, and metabolic abnormalities. Abnormalities in the steroidogenic pathway of both theca and granulosa cells have previously been reported, but there has been no comprehensive analysis of steroidogenic gene expression in granulosa-lutein (GL) cells of women with PCOS. In this study, we investigated a panel of genes invo...

ra0002o001 | SRF Post Doctoral Prize Session | SRF2015

Hyperandrogenism modulates adipokine gene expression in mouse adipocytes: implications for PCOS

Lerner Avi , Kewada Drashti , Okolo Anthony , Hardy Kate , Franks Stephen

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with anovulatory infertility, menstrual disturbances as well as an adverse metabolic profile. Hyperandrogenism is the hallmark of PCOS and originates predominantly from ovarian theca cells. Obesity increases androgen synthesis, partly due to accompanying hyperinsulinemia but also as a result of an effect of adipokines on ovarian steroidogenesis (Comim et al. PLoS ONE 8</str...

ra0002o019 | SRF Student Prize Session | SRF2015

Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure

Siemienowicz Katarzyna Joanna , Rae Mick , Lerner Avi , Franks Stephen , Duncan W Colin

Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance and obesity. Obesity is associated with increased energy intake or reduced energy expenditure. In this context, postprandial thermogenesis (PPT), is an important constituent of energy expenditure.Our lab utilizes a clinically realistic ovine model of PCOS, where pregnant Scottish G...

ra0003o027 | Oral Communications 3: Environmental and programming effects on reproduction | SRF2016

Androgen causes whitening of brown adipose tissue: Implications for PCOS

Lerner Avi , Kewada Drashti , Ahmed Ayan , Okolo Anthony , Christian Mark , Hardy Kate , Franks Stephen

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with hyperandrogenism- and an adverse metabolic profile including obesity and insulin resistance. Women with PCOS and raised androgen levels exhibit reduced postprandial thermogenesis and this is thought to predispose women with PCOS to weight gain (Robinson et al., 1992, Clin Endocrinol 36: 537–543). Brown adipose tissue (BAT) is important in the dissipation of energy in the form of heat and c...

ra0003p059 | (1) | SRF2016

Insight into the molecular mechanisms underlying enhanced gonadotropin hormone receptor activity in polycystic ovarian syndrome

Owens Lisa , Lerner Avi , Christopoulos George , Liyanage Maneshka , Islam Rumana , Lavery Stuart , Tsui Vicky , Hardy Kate , Franks Stephen , Hanyaloglu Aylin

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 5–10% of women of reproductive age, and is the major cause of anovulatory infertility and hyperandrogenism. Aberrant secretion and or action of gonadotropins are implicated but, to date, we have only limited knowledge about the precise mechanisms that are involved. Recent genome wide association studies have discovered significant signals have emerged at loci close to the genes on chr...

ra0002p035 | (1) | SRF2015

Differential gene expression in granulosa–lutein cells from women with polycystic ovaries is independent of the dose of FSH given for ovarian stimulation

Velupillai Jocelyne , Lerner Avi , Christopoulos Georgios , Liyanage Maneshka , Lavery Stuart , Trew Geoffrey , Laird Mhairi , Mora Jocelyn M , Tsui Victoria , Hardy Kate , Franks Stephen

Polycystic ovary syndrome (PCOS) affects over 5% of women of reproductive age. It is associated with an ovulatory infertility, menstrual disturbances as well as metabolic abnormalities including obesity and insulin resistance. PCOS has a strong genetic basis but studies of ovarian gene expression in PCOS are limited by the difficulty in obtaining tissue samples from women with and without PCOS. For that reason, most studies have been performed in granulosa–lutein (GL) cel...