Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002o014 | SRF Student Prize Session | SRF2015

Maternal protein restriction around conception reduces the neural stem cells during mouse fetal brain development and alters neuronal differentiation during gestation

Gould Joanna Mary , Fleming Tom , Airey Chris J , Marfy-Smith Stephanie Jane , Willaime-Morawek Sandrine

Maternal malnutrition during pregnancy is detrimental to fetal development and increases the risk of many chronic diseases in later life i.e. neurological consequences such as increased risk of schizophrenia. Previous studies have shown maternal protein malnutrition during pregnancy and lactation compromises brain development in late gestation and after birth, affecting structural, biochemical, and pathway dynamics with lasting consequences for motor and cognitive function. Ho...

ra0003o020 | SRF Student Prize Session | SRF2016

Maternal high fat diet (HFD) in the adult offspring brain modifies cell density and neuronal density

Pedraza Diego Ojeda , Jane-Coupe Kate , Earl Megan , Hutton Oliver , Eckert Judith , Willaime-Morawek Sandrine

Introduction: An upward trend in maternal obesity is rising every year. Different data suggest that maternal obesity during gestation may have effects on a high risk of children of developing physiological and psychological dysfunctions in later life. Animal models suggest that a maternal high fat diet (HFD) during pregnancy could have enduring consequences on brain structure and development in the offspring. Our aim is to evaluate the effects of maternal HFD on both offspring...

ra0003o024 | Oral Communications 3: Environmental and programming effects on reproduction | SRF2016

Maternal protein restriction around conception alters the foetal mouse brain by reducing the neural stem cells and increasing neuronal differentiation during gestation, which might be associated with the adult behavioural deficits

Gould Joanna , Pearson-Farr Jenny , Airey Chris , Semmence Oliver , Gould Philippa , Willaime-Morawek Sandrine , Fleming Tom

Introduction: Maternal malnutrition during pregnancy is detrimental to fetal development and increases the risk of many chronic diseases in later life i.e. neurological consequences such as increased risk of schizophrenia. Previous studies have shown maternal protein malnutrition during pregnancy and lactation compromises brain development in late gestation and after birth, affecting structural, biochemical and pathway dynamics with lasting consequences for motor and cognitive...

ra0001p025 | Stem cells and reprogramming | WCRB2014

The role of maternal low protein diet on neural stem cells and neurogenesis in the offspring brain?

Airey Chris J , Smith Phoebe J , Gould Joanna M , Marfy-Smith Stephanie J , Fleming Tom P , Willaime-Morawek Sandrine

Globally, malnutrition is the single greatest threat to public health. Maternal malnutrition during pregnancy is detrimental to foetal development and increases the risk of many chronic diseases in later life. Neurological consequences include increased risk of schizophrenia and abnormal anxiety-related behaviour. Previous studies have shown that maternal protein restriction has a negative effect on foetal brain development in vivo and we previously showed an effect o...

ra0001p106 | (1) | WCRB2014

Genome-wide DNA methylation analysis of bovine clones derived from the same donor cells

Kaneda Masahiro , Watanabe Shinya , Hirako Makoto , Akagi Satoshi , Kiefer Helene , Jouneau Luc , Martin-Magniette Marie-Laure , Balzergue Sandrine , Nagai Takashi

Introduction: What is nature versus nurture? To what extent do genetic inheritance and non-genetic factors contribute to one’s character? This is one of the oldest issues in psychology. To answer this historic question, cloned animals are good models because they have identical genetic information to the donors. Previous studies indicated that cloned animals showed different coat color patterns, noseprints and characters compared to the donors. However, no molecular work ...