Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002o019 | SRF Student Prize Session | SRF2015

Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure

Siemienowicz Katarzyna Joanna , Rae Mick , Lerner Avi , Franks Stephen , Duncan W Colin

Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance and obesity. Obesity is associated with increased energy intake or reduced energy expenditure. In this context, postprandial thermogenesis (PPT), is an important constituent of energy expenditure.Our lab utilizes a clinically realistic ovine model of PCOS, where pregnant Scottish G...

ra0002p031 | (1) | SRF2015

Does maternal progesterone supplementation in early pregnancy affect fetal development?

Mareckova Magda , Siemienowicz Katarzyna Joanna , Wang Yili , Rae Mick , Duncan W Colin

Some adult diseases are programmed in utero by fetal exposure to abnormal concentrations of steroid hormones. Threatened miscarriage in early pregnancy is treated by progesterone in many countries although robust evidence of efficacy is lacking. We hypothesised that increased progesterone concentrations may alter fetal development. In a small pilot study, using a pregnant sheep model, we administered 200 mg progesterone twice weekly from d20–d75 of gestation and ...

ra0003o016 | SRF Student Prize Session | SRF2016

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS)

Siemienowicz Katarzyna , Coukan Flavien , Lerner Avigdor , Franks Stephen , Rae Mick , Duncan Colin

Women with Polycystic Ovary Syndrome are at increased risk of developing insulin resistance, obesity and dyslipidemia. Amplified metabolic perturbations during puberty may be a central factor contributing to metabolic phenotype of adult PCOS. Using a clinically realistic ovine model of PCOS we reported hyperinsulinaemia and early fatty liver changes, with no difference in body weight and adiposity, in adolescence.Here we aimed to further examine metaboli...