Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002p041 | (1) | SRF2015

Regulation of CyclinD2 by Smad3 and Foxl2 during early follicle development

Granados-Aparici Sofia , Sharum Isam , Hardy Kate , Franks Stephen , Waite Sarah , Chapman Neil , Fenwick Mark

Introduction: Primordial follicles are relatively quiescent structures that form the basis of the ovarian reserve. Maintenance of the quiescent state, and conversely, release from this state towards irreversible growth, involves mechanisms that are currently unresolved. Two transcription factors have been implicated alongside this process in granulosa cells (GCs). Specifically, Smad3 was recently identified in the nuclei of GCs in small single-layered follicles whereas Foxl2 i...