SRF2015 POSTER PRESENTATIONS (1) (56 abstracts)
Sex specific effects of maternal dietary protein during the periconceptional period upon hepatic gene expression in heifer progeny
Janna Morrison 1 , Katrina J Copping 2 , Juan H Hernandez-Medrano 3 , Raymond Rodgers 2 , Caroline McMillen 4 & Viv E A Perry 3
1University of South Australia, Adelaide, Australia; 2University of Adelaide, Adelaide, Australia; 3University of Nottingham, Loughborough, UK; 4University of Newcastle, Newcastle, Australia.
Sex specific expression occurs in 20–30% of all hepatic genes in the adult animal (1). We have shown that there is an interaction between gender and the level of maternal dietary protein intake on bovine fetal development as early as 36–39 days post conception (dpc) We hypothesise that exposure to different levels of maternal protein intake in the periconceptional period (60d preconception to 23dpc) and in the postconceptional period (23–98dpc) will result in a differential pattern of gene expression in the male and female fetal bovine liver at 98 dpc. We found that high protein intake resulted in an increase in the hepatic expression of the glucocorticoid receptor (GR) (P<0.01) in the female fetus only. Similarly a high protein intake in the periconception period resulted in an increase in the hepatic expression of the gluconeogenic factors, PEPCK-C (P=0.05), PGC-1α (P<0.05) and PDK-1(P<0.05) in female. Low protein given periconceptionally effected increased expression of genes permissive to lipogenesis; PPARγ (P<0.01) and RXR (P<0.01) in the female liver. The expression of Fox01, a transcription factor with a key role in insulin signalling and gluconeogenesis, was increased in both sexes after exposure to a high protein diet in the periconceptional period. Our findings highlight the sex specific sensitivity of the epigenome to maternal nutrition around conception and very early gestation. Furthermore, such effects may have functional consequences in the decreased sensitivity of the hepatic insulin signalling pathway (2).
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ISSN 2052-1472 (online)
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