Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p046 | (1) | SRF2016

Dynamic changes in expression and DNA methylation of the astrocyte-specific genes Slc1a2 and Lrg1 during development: implications for preterm birth?

Allen Caroline , Cartier Jessy , Drake Amanda

Introduction: Preterm birth associates with later neurological conditions. Many of the underlying mechanisms are unknown however studies suggest changes in DNA methylation may be important. We have previously identified differential DNA methylation at astrocyte-specific genes, Slc1a2 and Lrg1 in preterm infants. Here we set out to describe the normal developmental patterns of gene expression and DNA methylation of Slc1a2 and Lrg1 in vivo in an animal model and assessed the pot...