Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p051 | (1) | SRF2016

The effect of macrophage colony-stimulating factor (CSF1) on piglet gonad development

Ashworth Cheryl , Avey Billie , Stenhouse Claire , Sauter Kristin , Waddell Lindsey , Hogg Charis , Lisowski Zofia , Hume David

Introduction: CSF1 is the primary growth factor required for macrophage proliferation and differentiation. In adults, the receptor is expressed only in macrophages and their precursors. In mice, mutation of the CSF1 gene produces both male and female infertility due to diminished gonadal steroid production. We tested the effect of increased availability of CSF1 on gonadal development in pigs using CSF1-Fc, a CSF1 fusion protein with increased circulating half-life.<p class...