Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002o011 | Oral Communications 2: Ovarian function | SRF2015

The role of the oocyte is investigated in premature ovarian failure using the reaggregated ovarian pellet technique

Sheikh Sairah , Galaz Heidy Kaune , Deleva Anna , Williams Suzannah A

Premature ovarian failure (POF) affects around 1% of women and is idiopathic in 74–90% of cases. Our mouse model of POF, the double mutant (DM), are fertile at 6-weeks and undergo POF by 3-months consistent with a decline in developing follicles. However, DM ovaries have increased numbers of primary follicles at the 3a stage, indicating a block in follicle development.We investigated whether we could rescue the ability of DM oocytes at 3- and 9-week...

ra0003p047 | (1) | SRF2016

Germ cells, from a mouse model of Premature Ovarian Failure, retain the potential to support follicle development when reaggregated with wildtype somatic cells

Sheikh Sairah , Kaune Heidy , Deleva Anna , Williams Suzannah

Introduction: Premature ovarian failure (POF) is a condition that affects ~1% of women and is idiopathic in 74–90% of cases. Our mouse model of POF, the Double Mutant (DM), results from oocyte-specific ablation of core 1-derivedO-glycans and complex and hybrid N-glycans. DM females are subfertile at 6-weeks of age and infertile at 9-weeks of age. By 3 months, DM females exhibit POF with ovaries containing fewer developing follicles but more primary 3a follicles. We invest...