Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002o013 | Oral Communications 2: Ovarian function | SRF2015

The oocyte induces estrus stage-specific changes in theca cells and their extracellular matrix

Christensen Alice Pearl , Ploutarchou Panayiota , Grasa Patricia , Williams Suzannah A

The oocyte influences hormonal and cellular changes in the follicle and the ovary. Theca cells, surrounding the follicle basement membrane, synthesise androgen and thus regulate ovarian oestrogen production. The vascular theca layer provides nutrients to the avascular inner follicle. In C1galt1 mutant mice, all oocytes lack core 1-derived O-glycans due to oocyte-specific ablation of core 1 beta 1,3-galactosyltransferase. C1galt1 mutants have increase...

ra0003o001 | Oral Communications 1: Ovary | SRF2016

Mice with follicular premature ovarian failure at 3 months of age become a follicular by 1 year of age

Plumb Betsy , Sheikh Sairah , Grasa Patricia , Ploutarchou Panayiota , Williams Suzannah

Introduction: Premature ovarian failure (POF) is a reproductive disorder which causes defects within the ovaries, normally leading to infertility. The disorder affects 1% of women under the age of 40 with 75% of cases with no known cause, indicating the need for more research. The Double Mutant (DM) mouse model with oocyte-specific deletion of C1galt1 and Mgat1 exhibit follicular POF at 3 months of age. Therefore, this study aimed to investigate the effect of ovarian dysfuncti...