Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p018 | (1) | SRF2016

Establish of a transgenic neural cell line with an astrocyte-specific inducible CreERT2 system

Hwang Seon-Ung , Yoon Junchul David , Han Yongquan , Eun Kiyoung , Kim Hyunggee , Hyun Sang-Hwan

Transgenic (TG) pigs are currently regarded as an important animal model for various biomedical researches including a disease modeling and a regenerative medicine. We tried to develop a pig astrocyte-specific CreERT2-LoxP recombination system as a part of TG pig model of brain tumor arisen from astrocytic cell lineage. We designed two vector systems one retains pig glial fibrillary acidic protein (GFAP) promoter-CreERT2 transgene and the other has GFP ge...