Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p059 | (1) | SRF2016

Insight into the molecular mechanisms underlying enhanced gonadotropin hormone receptor activity in polycystic ovarian syndrome

Owens Lisa , Lerner Avi , Christopoulos George , Liyanage Maneshka , Islam Rumana , Lavery Stuart , Tsui Vicky , Hardy Kate , Franks Stephen , Hanyaloglu Aylin

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 5–10% of women of reproductive age, and is the major cause of anovulatory infertility and hyperandrogenism. Aberrant secretion and or action of gonadotropins are implicated but, to date, we have only limited knowledge about the precise mechanisms that are involved. Recent genome wide association studies have discovered significant signals have emerged at loci close to the genes on chr...