Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003o008 | Oral Communications 2: Early Development 1 | SRF2016

Mouse blastocyst implantation in an in vitro model is promoted by early apposition with the uterine epithelium and by hyperosmolar stress

Ruane Peter , Koeck Rebekka , Kimber Sue , Brison Daniel , Westwood Melissa , Aplin John

Implantation failure remains a bottleneck in assisted reproduction treatments (ARTs), as only ~25% of treatment cycles result in a live birth. During the early stages of implantation, endocrine and embryonic paracrine signals prime the receptivity of the uterine luminal epithelium (LE) before the trophectoderm (TE) of the blastocyst-stage embryo can mediate attachment and subsequently invade the uterine epithelium and stroma. We have developed an in vitro model using ...