Searchable abstracts of presentations at key conferences on reproductive biology and medicine
Previous issue | Volume 3 | SRF2016

Society for Reproduction and Fertility Annual Conference 2016

Winchester, UK
11 Jul 2016 - 11 Jul 2016

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Oral Communications 2: Early Development 1

ra0003o007 | Oral Communications 2: Early Development 1 | SRF2016

Cyclical DNA methyltransferase and histone deacetylase expression across multiple timescales in the uterus of the Siberian hamster (Phodopus sungorus)

Lynch Eloise , Coyle Chris , Stevenson Tyler

Introduction: It is becoming clear that epigenetic modifications, such as DNA methylation, exhibit dynamic and reversible changes. Our understanding of a role for epigenetic modifications for timing biological rhythms is in its infancy. It has recently been found that DNA methylation in the hypothalamus plays a role in regulating the internal representation of seasonal timing. Here we tested the hypothesis that epigenetic modifications are also responsible for controlling repr...

ra0003o008 | Oral Communications 2: Early Development 1 | SRF2016

Mouse blastocyst implantation in an in vitro model is promoted by early apposition with the uterine epithelium and by hyperosmolar stress

Ruane Peter , Koeck Rebekka , Kimber Sue , Brison Daniel , Westwood Melissa , Aplin John

Implantation failure remains a bottleneck in assisted reproduction treatments (ARTs), as only ~25% of treatment cycles result in a live birth. During the early stages of implantation, endocrine and embryonic paracrine signals prime the receptivity of the uterine luminal epithelium (LE) before the trophectoderm (TE) of the blastocyst-stage embryo can mediate attachment and subsequently invade the uterine epithelium and stroma. We have developed an in vitro model using ...

ra0003o009 | Oral Communications 2: Early Development 1 | SRF2016

A novel role of Adam 10 in tight junction formation during mouse preimplantation development

Choi Inchul , Jeong Ye-lin

A Disintegrin and Metalloprotease Domain-containing protein 10 (ADAM10) is a cell surface protein with a unique structure possessing potential adhesion and protease domains. However, the role of ADAM10 is not known during early embryo development. In this study, we investigated the expression patterns and biological function of Adam10 in mouse preimplantation embryos. The transcription level of Adam10 increased from the two-cell stage onward. Immunostaining revealed t...

ra0003o010 | Oral Communications 2: Early Development 1 | SRF2016

Investigating of the role of Tribbles-2 protein in mammalian embryo implantation

Basatvat Shaghayegh , Carter Deborah L.A. , Kiss-Toth Endre , Fazeli Alireza

Introduction: Embryo implantation is a complex and highly regulated process. Toll-Like receptors (TLRs) play a strategic role in recognition of pathogens in female reproductive tract. Activation of TLRs in endometrial cells at the time of embryo implantation appears to have negative effect on implantation. Tribbles-2 (Trib2) protein is members of tribbles family of psuedokinase proteins, modulating TLR5 signal transduction pathway.Tribbles-2 knockout female mice are infertile....

ra0003o011 | Oral Communications 2: Early Development 1 | SRF2016

Investigating O-GlcNAcylation in an in vitro model used to mimic diabetes, and its effects on implantation

Watts Jessica , Ruane Peter , Aplin John , Westwood Melissa

The incidence of diabetes has increased in recent decades and by 2030, 366 million people worldwide will have the disease a significant proportion of these will be women of reproductive age. Diabetes is known to reduce fecundity and increase the likelihood of early pregnancy loss we propose that the high glucose levels seen in diabetes influence maternal fertility by impairing endometrial receptivity/function as a result of increased flux in the hexosamine biosynthetic pathway...

ra0003o012 | Oral Communications 2: Early Development 1 | SRF2016

Efficacy of progestogen supplementation in women undergoing assisted reproductive technology treatment: A meta-analysis

Mohammed Amal , Woad Kathryn , Mann George , Robinson Robert

Introduction: Luteal phase deficiency following assisted reproductive technology (ART) programmes has led to progestogen supplementation. However, there is debate over which route of progestogen administration (intramuscular or vaginal) is most beneficial and whether additional treatment with oestrogen further improves pregnancy rates. Thus, a large-scale meta-analysis was performed to investigate the benefit of these luteal phase support treatments on pregnancy outcome in wom...