Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003o016 | SRF Student Prize Session | SRF2016

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS)

Siemienowicz Katarzyna , Coukan Flavien , Lerner Avigdor , Franks Stephen , Rae Mick , Duncan Colin

Women with Polycystic Ovary Syndrome are at increased risk of developing insulin resistance, obesity and dyslipidemia. Amplified metabolic perturbations during puberty may be a central factor contributing to metabolic phenotype of adult PCOS. Using a clinically realistic ovine model of PCOS we reported hyperinsulinaemia and early fatty liver changes, with no difference in body weight and adiposity, in adolescence.Here we aimed to further examine metaboli...

ra0003p061 | (1) | SRF2016

Altered expression of genes affecting oestrogen metabolism and action in granulosa-lutein cells of women with PCOS

Coates Melanie , Lerner Avigdor , Christopoulos Georgios , Liyanage Maneshka , Lavery Stuart , Tsui Victoria , Hardy Kate , Franks Stephen

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in premenopausal women and is associated with hyperandrogenism, anovulatory infertility, and metabolic abnormalities. Abnormalities in the steroidogenic pathway of both theca and granulosa cells have previously been reported, but there has been no comprehensive analysis of steroidogenic gene expression in granulosa-lutein (GL) cells of women with PCOS. In this study, we investigated a panel of genes invo...