Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003o002 | Oral Communications 1: Ovary | SRF2016

The effect of folic acid supplementation during the juvenile pubertal period or adulthood on gene expression in the ovary

Escarate Reyna Penailillo , Burton Mark , Burdge Graham , Eckert Judith , Fleming Tom , Lillycrop Karen

Introduction: Women with mutations in BRCA1 gene have an increased lifetime risk of ovarian cancer. Many studies but not all have shown that an adequate folate intake is protective against many cancers including ovarian, but recent studies have shown that high levels of folic acid (FA) supplementation can promote cancer risk. The aim of this study is to determine FA impact on the expression of cancer related genes in the ovary such as OCT4 a pluripotency factor, BRCA1 related ...