Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p022 | Ovary | WCRB2014

Wnt5a is a crucial regulator of ovarian follicle development and female fertility in mice

Abedini Atefeh , Rico Charlene , Price Christopher A , Boerboom Derek

Introduction: The WNT signaling pathway plays important roles in sex determination and embryonic development. Previous results indicated that WNT4 is required for normal ovarian follicle development and fertility and that WNT4 and WNT5a play redundant roles in regulating oocyte entry into meiosis during embryogenesis, suggesting potential redundant roles of WNT4 and WNT5a in the ovary. The objective of this study was to determine the effect of granulosa cell-conditional knock-...