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Reproduction Abstracts (2016) 3 P042 | DOI: 10.1530/repabs.3.P042


Comparative investigation of lipid peroxidation and antioxidant enzymes in relation to semen quality

Muhammad Riaz1, Zahed Mahmood1,2, Muhammad Usman Qamar Saeed1,3 & Muhammad Shahid1


1Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan; 2Department of Applied Chemistry and Biochemistry, Government College University Faisalabad, Faisalabad, Pakistan; 3Department of Pathology, Civil Hospital, Bahawalpur, Pakistan.

Introduction: Lipid peroxidation is considered as an important mechanism of male infertility causing impairment in functioning of spermatozoa. The main aim of the study was to investigate the lipid peroxidation and antioxidant enzymes in relation to semen quality.

Materials and methods: For this study total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), arylesterase and malondialdehyde (MDA) were investigated in seminal plasma and serum of all study subjects by photometric method. Semen quality parameters were also examined following standard protocols.

Results and discussion: We found significantly (P<0.01) reduced semen quality parameters in infertile group. The results also showed that TOS and MDA were increased significantly (P<0.01) while TAS, PON and arylesterase were found significantly (P<0.01) lower in infertile group when compared to fertile group. We also found an increased lipid peroxidation in older ages as compared to younger ages. Moreover, significant (P<0.01) correlation was also observed between the studied parameters. We concluded that lipid peroxidation plays a significant role in inducing male factor infertility by disrupting the sperm functions and semen quality.

Volume 3

Society for Reproduction and Fertility Annual Conference 2016

Winchester, UK
11 Jul 2016 - 11 Jul 2016

Society for Reproduction and Fertility 

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