Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p205 | (1) | WCRB2014

The impact of oxidative stress on chaperone-mediated human sperm–egg interaction

Grace Bromfield Elizabeth , Nixon Brett , Redgrove Kate , Aitken Robert John

Introduction: Defective sperm–egg recognition is recognised as one of the major causes of failed fertilization in IVF programs. Our recent findings have revealed that such defects may be linked to the molecular chaperone, heat shock protein A2 (HSPA2), due to its ability to facilitate the formation of multimeric zona pellucida (ZP)-receptor complexes on the surface of human spermatozoa. This study aimed to examine the impact of oxidative stress on the formation of these Z...