Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p222 | (1) | WCRB2014

The RNA-binding protein Musashi-2 (MSI2) controls mRNA processing and translational regulation via interactions with SFPQ and PIWIL1 during mammalian spermatogenesis

Sutherland Jessie M , Sobinoff Alexander P , Redgrove Kate , Davidson Tara-Lynne , Siddall Nicole A , Koopman Peter , Hime Gary R , McLaughlin Eileen

Introduction: RNA-binding proteins (RBP) are important catalysts of post-transcriptional gene regulation. The RBP MSI2 directs stem cell function and division through established roles in cell cycle dynamics and cell fate determination. During the complex process of mammalian spermatogenesis, the directed uncoupling of transcription and translation is essential for the correct development of male gametes. We have previously established that dysregulation of MSI2 during germ ce...

ra0002s004 | SRF-SRB Exchange Lecture | SRF2015

SRF–SRB Exchange Lecture: Musashi RNA binding protein MSI2 interacts with SFPQ and controls the expression of target mRNAs Tbx1 and Piwil1 in male germ cells during spermatogenesis

Sutherland Jessie M , Fraser Barbara A , Sobinoff Alexander P , Siddall Nicole A , Koopman Peter , Hime Gary R , McLaughlin Eileen A

Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the process of gamete development, male germ cells experience extended periods of inactive transcription despite requirements for continued growth and differentiation. Spermatogenesis therefore provides an ideal model to study the effects of post-transcriptional control on gene regulation. During spermatogenesis post-transcriptional regulation is orchestrated by abundan...