Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p212 | (1) | WCRB2014

Androgen receptor signalling in testicular Leydig cells is essential for Leydig cell maturation and survival

O'Hara Laura , McInnes Kerry , Simitsidellis Ioannis , Morgan Steph , Milne Laura , Mitchell Rod , Smith Lee

Androgen receptor (AR) is expressed by testicular somatic cells including steroidogenic Leydig cells (LC). Its role in LC is ill defined, with hypotheses based on evidence from total androgen receptor knockout models implying that LC AR is responsible for final LC number, regulation of steroidogenic enzyme expression and LC maturation.To better define the role of AR in LC, we generated a mouse line with a LC specific ablation of AR (LCARKO) using the Cre...