Searchable abstracts of presentations at key conferences on reproductive biology and medicine
Volume 1 | WCRB2014 | Next issue

World Congress of Reproductive Biology 2014

Edinburgh, UK
02 Sep 2014 - 04 Sep 2014

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World Congress on Reproductive Biology 2014, 02 - 04 September 2014; Edinburgh, UK

SYMPOSIA

Control of meiosis

ra0001s027 | Control of meiosis | WCRB2014

Environmental effects on gametogenesis: it all depends on sex

Hunt Patricia

Gametogenesis is a complex process with striking sexual dimorphism. Although oogenesis and spermatogenesis share several global features (e.g., the production of haploid cells through meiotic divisions and extended periods of gamete maturation), the timing of events, their order and the propensity for errors during the process differ markedly. Our interest is in the factors – both endogenous (e.g., age) and endogenous (e.g., environmental exposures) – that influence ...

ra0001s028 | Control of meiosis | WCRB2014

Making it through meiosis: APC/C FZR1 has an essential role in meiotic prophase I in germ cell development

McLaughlin Eileen A

Fizzy-related 1 (FZR1) is one of two known activators of the anaphase promoting complex (APC) and a well-established important regulator of the mitotic cell cycle. In a germ-cell-specific (DDX4-cre) conditional knockout model we examined the role of FZR1 in germ cell development with particular emphasis on the entry into meiosis and early meiotic events. Loss of APC FZR1 activity in the male germline led to both a mitotic and a meiotic cell defect resulting in sterility throug...

ra0001s029 | Control of meiosis | WCRB2014

Major causes of age-related chromosome segregation errors at meiosis I in oocytes

Kitajima Tomoya S

Chromosomes must be properly segregated during meiosis to transmit the correct set of the parental genome into gametes. Incorrect chromosome segregation produces aneuploid gametes, fertilization of which results in pregnancy loss and congenital diseases such as Down syndrome. However, it is known that the frequency incorrect chromosome segregation is extremely high at meiosis I in oocytes (20–40% in humans), compared to other cell divisions. Moreover, the frequency of the...