Searchable abstracts of presentations at key conferences on reproductive biology and medicine
Volume 1 | WCRB2014 | Next issue

World Congress of Reproductive Biology 2014

Edinburgh, UK
02 Sep 2014 - 04 Sep 2014

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World Congress on Reproductive Biology 2014, 02 - 04 September 2014; Edinburgh, UK


Testis biology and spermatogenesis

ra0001s005 | Testis biology and spermatogenesis | WCRB2014

The contributions of importin proteins to spermatogenesis: roles in signalling, gene transcription and stress responses

Miyamoto Yoichi , Whiley Penny , Young Julia , Arjomand Arash , Yoneda Yoshihiro , Jans David A , Loveland Kate L

Importin protein family members are best known for serving critical roles in mediating regulated nucleocytoplasmic transport, and many are essential to developmental events including gametogenesis. We proposed that coordinated expression of an importin and a cell-specific transcription factor would drive a developmental switch by enabling transcription and other nuclear factors to enter the nucleus appropriately. Analyses of importin alpha (IMPĪ±) and beta (IMPĪ²) mRNA...

ra0001s006 | Testis biology and spermatogenesis | WCRB2014

What have we learned about the testis from cell ablation studies

O'Shaughnessy Peter , Rebourcet Diane , Smith Lee

Cell ablation is a powerful technique for examining the role of a particular cell type in organ development and function. The utility of the technique is dependent upon the ablation being specific to one cell type and for those of us interested in the testis we have been fortunate that methods have existed for some time to ablate the germ cells and the Leydig cells. Recently we have also developed a transgenic mouse model which expresses the diphtheria toxin receptor (DTR) spe...

ra0001s007 | Testis biology and spermatogenesis | WCRB2014

The role of autophagy in spermatogenesis

Wang Hongna , Li Wei

Acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosome-related organelle (LRO) is still largely unknown. Here we show that germ cell specific Atg7 knockout mice were infertile due to defect in acrosome biogenesis and displayed a phenotype of human globozoospermia, and this reproductive defect was successfully rescued by...