Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p096 | (1) | WCRB2014

Insulin and branched-chain amino acid depletion during mouse in vitro preimplantation development alters postnatal growth and cardiovascular physiology

Velazquez Miguel Abraham , Sheth Bhav , Marfy-Smith Stephanie , Eckert Judith , Fleming Tom

Introduction: Maternal depletion of insulin in serum and branched-chain amino acids (BCAA) in uterine luminal fluid occurs in response to dietary protein undernutrition during the periconceptional period which leads to adverse offspring growth and cardiovascular phenotype (e.g. high blood pressure). This study aimed to determine whether insulin and/or BCAA depletion might be inductive in vivo factors for postnatal phenotype using an in vitro embryo culture mo...

ra0003o002 | Oral Communications 1: Ovary | SRF2016

The effect of folic acid supplementation during the juvenile pubertal period or adulthood on gene expression in the ovary

Escarate Reyna Penailillo , Burton Mark , Burdge Graham , Eckert Judith , Fleming Tom , Lillycrop Karen

Introduction: Women with mutations in BRCA1 gene have an increased lifetime risk of ovarian cancer. Many studies but not all have shown that an adequate folate intake is protective against many cancers including ovarian, but recent studies have shown that high levels of folic acid (FA) supplementation can promote cancer risk. The aim of this study is to determine FA impact on the expression of cancer related genes in the ovary such as OCT4 a pluripotency factor, BRCA1 related ...

ra0003o020 | SRF Student Prize Session | SRF2016

Maternal high fat diet (HFD) in the adult offspring brain modifies cell density and neuronal density

Pedraza Diego Ojeda , Jane-Coupe Kate , Earl Megan , Hutton Oliver , Eckert Judith , Willaime-Morawek Sandrine

Introduction: An upward trend in maternal obesity is rising every year. Different data suggest that maternal obesity during gestation may have effects on a high risk of children of developing physiological and psychological dysfunctions in later life. Animal models suggest that a maternal high fat diet (HFD) during pregnancy could have enduring consequences on brain structure and development in the offspring. Our aim is to evaluate the effects of maternal HFD on both offspring...