Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p252 | (1) | WCRB2014

Roles of testicular macrophage in Leydig cell proliferation in colony-stimulating factor treated mice

Tsai Tina , Sauter Kristin , Milne Laura , Hume David , Smith Lee

Introduction: Leydig cells (LCs), the key producer of testosterone (T) in the testis, are affected by various factors such as hormone stimulation. There are various testicular cells that also affect LC function such as testicular interstitial macrophages (TIMs). TIMs are immune factor-producing cells, located adjacent to the LCs, sharing a close physiological and functional relationship. TIMs are associated with development and function of LCs. Ablation of TIMs have shown to i...

ra0003p051 | (1) | SRF2016

The effect of macrophage colony-stimulating factor (CSF1) on piglet gonad development

Ashworth Cheryl , Avey Billie , Stenhouse Claire , Sauter Kristin , Waddell Lindsey , Hogg Charis , Lisowski Zofia , Hume David

Introduction: CSF1 is the primary growth factor required for macrophage proliferation and differentiation. In adults, the receptor is expressed only in macrophages and their precursors. In mice, mutation of the CSF1 gene produces both male and female infertility due to diminished gonadal steroid production. We tested the effect of increased availability of CSF1 on gonadal development in pigs using CSF1-Fc, a CSF1 fusion protein with increased circulating half-life.<p class...